The story so far? Possible GI alkalinity and the possibility that I am extremely sensitive to emotional contagion.
The latest results of my internet scavenging, prompted by a desire to figure out why Adderall doesn't linger in my system as it should, are complex to say the least. A tip from a forum led to an investigation of pharmocokinetics, specifically the population-specific variations of a certain liver enzyme of the P450 group. This enzyme, CYP2D6, is primarily responsible for drug metabolism and, interestingly enough, can vary in effecacy among ethnic populations depending on the particular type or types present.
Basically, one type of CYP2D6 is seen in poor metabolizers, another is seen in normal metabolizers, and multiples are seen in ultra-rapid metabolizers.
Being an ultra-rapid metabolizer would explain why Adderall practically disappears in my system, but there's the teeny-tiny fact that a significant percentage of the ethnic population to which I belong are poor metabolizers and that ultra-rapid metabolizers are rare in said population.
I did find some articles about a new variant of a different drug metabolizing liver enzyme that was specific to my ethnic profile, but details were lacking and I was getting lost in the scientific terminology.
Maybe a search just in MedPub would unearth more.
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