"When the deep limbic system is less active there is generally a positive, more hopeful state of mind. When it is heated up, or overactive, negativity can take over. This finding actually surprised us at first. We thought that excessive activity in the part of the brain that controlled emotion might correlate with enhanced feelings, not necessarily negative feelings. Yet, we noticed, again and again, when this area was overactive on SPECT it correlated with depression and negativity."
Which makes me wonder if increased limbic activity burns through the depression linked neurotransmitters faster, which results in depression. Of course, there's that whole cortisol link as well...
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